Nanometer-scale views of visual cortex reveal anatomical features of primary cilia poised to detect synaptic spillover.

ABSTRACT: A primary cilium is a thin membrane-bound extension off a cell surface that contains receptors for perceiving and transmitting signals that modulate cell state and activity. While many cell types have a primary cilium, little is known about primary cilia in the brain, where they are less accessible than cilia on cultured cells or epithelial tissues and protrude from cell bodies into a deep, dense network of glial and neuronal processes. Here, we investigated cilia frequency, internal structure, shape, and position in large, high-resolution transmission electron microscopy volumes of mouse primary visual cortex. Cilia extended from the cell bodies of nearly all excitatory and inhibitory neurons, astrocytes, and oligodendrocyte precursor cells (OPCs), but were absent from oligodendrocytes an

SUBMITTER: Ott CM 

PROVIDER: S-EPMC10635062 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature