Plasma-based antigen persistence in the post-acute phase of SARS-CoV-2 infection.

ABSTRACT:

Background

Persistent symptoms among some persons who develop COVID-19 has led to the hypothesis that SARS-CoV-2 may, in some form or location, persist for long periods following acute infection. Several studies have shown data in this regard but are limited by non-representative and small study populations, short duration since acute infection, and lack of a true-negative comparator group to assess assay specificity.

Methods

We evaluated adults with RNA-confirmed COVID-19 at multiple time points following acute infection (pandemic-era participants) and adults with specimens collected prior to 2020 (pre-pandemic era). Using once-thawed plasma, we employed the Simoa^® (Quanterix) single molecule array detection platform to measure SARS-CoV-2 spike, S1, and nucleocap

SUBMITTER: Peluso MJ 

PROVIDER: S-EPMC10635183 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature