C-reactive protein does not predict future depression onset in adolescents: preliminary findings from a longitudinal study.

ABSTRACT:

Introduction

Neuroinflammatory processes have been extensively implicated in the underlying neurobiology of numerous neuropsychiatric disorders. Elevated C-reactive protein (CRP), an indicator of non-specific inflammation commonly utilized in clinical practice, has been associated with depression in adults. In adolescents, our group previously found CRP to be associated with altered neural reward function but not with mood and anxiety symptoms assessed cross-sectionally. We hypothesized that the distinct CRP findings in adolescent vs. adult depression may be due to chronicity, with neuroinflammatory effects on psychiatric disorders gradually accumulating over time. Here, we conducted a longitudinal study to evaluate if CRP levels predicted future onset or progression of depression

SUBMITTER: Schwartz JJ 

PROVIDER: S-EPMC10635217 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature