<i>CXCL12</i> drives natural variation in coronary artery anatomy across diverse populations.

ABSTRACT: To efficiently distribute blood flow to cardiac muscle, the coronary artery tree must follow a specific branching pattern over the heart. How this pattern arises in humans is unknown due to the limitations of studying human heart development. Here, we leveraged a natural variation of coronary artery anatomy, known as coronary dominance, in genetic association studies to identify the first known driver of human coronary developmental patterning. Coronary dominance refers to whether the right, left, or both coronary arteries branch over the posterior left ventricle, but whether this variability is heritable and how it would be genetically regulated was completely unknown. By conducting the first large-scale, multi-ancestry genome-wide association study (GWAS) of coronary dominance in 61,043

SUBMITTER: Rios Coronado PE 

PROVIDER: S-EPMC10635223 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature