TWINGEN - protocol for an observational clinical biobank recall and biomarker study to identify individuals with high risk of Alzheimer's disease.

ABSTRACT:

Introduction

A better understanding of the earliest stages of Alzheimer's disease (AD) could expedite the development or administration of treatments. Large population biobanks hold the promise to identify individuals at an elevated risk of AD and related dementias based on health registry information. Here, we establish the protocol for an observational clinical recall and biomarker study called TWINGEN with the aim to identify individuals at high risk of AD by assessing cognition, health and AD-related biomarkers. Suitable candidates were identified and invited to participate in the new study among Finnish biobank donors according to TWINGEN study criteria.

Methods and analysis

A multi-center study (n=800) to obtain blood-based biomarkers, telephone-administered and web-ba

SUBMITTER: Vuoksimaa E 

PROVIDER: S-EPMC10635260 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature