Microtubule-Mediated Regulation of β₂AR Translation and Function in Failing Hearts.

ABSTRACT:

Background

β₁AR (beta-1 adrenergic receptor) and β₂AR (beta-2 adrenergic receptor)-mediated cyclic adenosine monophosphate signaling has distinct effects on cardiac function and heart failure progression. However, the mechanism regulating spatial localization and functional compartmentation of cardiac β-ARs remains elusive. Emerging evidence suggests that microtubule-dependent trafficking of mRNP (messenger ribonucleoprotein) and localized protein translation modulates protein compartmentation in cardiomyocytes. We hypothesized that β-AR compartmentation in cardiomyocytes is accomplished by selective trafficking of its mRNAs and localized translation.

Methods

The localization pattern of β-AR mRNA was investigated using single molecule fluorescence in si

SUBMITTER: Kwan Z 

PROVIDER: S-EPMC10635332 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature