Genome-wide association study of antisocial personality disorder diagnostic criteria provides evidence for shared risk factors across disorders.

ABSTRACT:

Introduction

While progress has been made in determining the genetic basis of antisocial behaviour, little progress has been made for antisocial personality disorder (ASPD), a condition that often co-occurs with other psychiatric conditions including substance use disorders, attention deficit hyperactivity disorder (ADHD), and anxiety disorders. This study aims to improve the understanding of the genetic risk for ASPD and its relationship with other disorders and traits.

Methods

We conducted a genome-wide association study (GWAS) of the number of ASPD diagnostic criteria data from 3217 alcohol-dependent participants recruited in the UK (UCL, N = 644) and the USA (Yale-Penn, N = 2573).

Results

We identified rs9806493, a chromosome 15 variant, that showed a genome-wide

SUBMITTER: Li W 

PROVIDER: S-EPMC10635348 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature