Maternal separation modifies spontaneous synaptic activity in the infralimbic cortex of stress-resilient male rats.

ABSTRACT: Glutamate and GABA signaling systems are necessary to maintain proper function of the central nervous system through excitation/inhibition (E/I) balance. Alteration of this balance in the medial prefrontal cortex (mPFC), as an effect of early-life stress, may lead to the development of anxiety and depressive disorders. Few studies exist in the infralimbic division of the mPFC to understand the effect of early-life stress at different ages, which is the purpose of the present work. Newborn Sprague Dawley male rats were subjected to maternal separation (MS) for two weeks. First, tests measuring anxiety- and depression-like behaviors were performed on adolescent and adult rats subjected to MS (MS-rats). Then, to establish a relationship with behavioral results, electrophysiological recordings

SUBMITTER: Ayala-Rodriguez JD 

PROVIDER: S-EPMC10635473 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature