Characterizing the phenotypic and genetic changes of pre-epidemic HIV-2 group F virus following serial passage in humanized mice.

ABSTRACT: HIV-2 Group F virus with an origin in NHPs was isolated from only two individuals. Two serial passages in hu-mice showed increased viral loads, CD4⁺ T cell decline and nonsynonymous genetic changes showing its capacity for further evolution, and spread in the human.

SUBMITTER: Curlin JZ 

PROVIDER: S-EPMC10635500 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature