Accurate prediction of pan-cancer types using machine learning with minimal number of DNA methylation sites.

ABSTRACT: DNA methylation analysis has been applied to determine the primary site of cancer; however, robust and accurate prediction of cancer types with a minimum number of sites is still a significant scientific challenge. To build an accurate and robust cancer type prediction tool with a minimum number of DNA methylation sites, we internally benchmarked different DNA methylation site selection and ranking procedures, as well as different classification models. We used The Cancer Genome Atlas dataset (26 cancer types with 8296 samples) to train and test models and used an independent dataset (17 cancer types with 2738 samples) for model validation. A deep neural network model using a combined feature selection procedure (named MethyDeep) can predict 26 cancer types using 30 methylation sites with

SUBMITTER: Ning W 

PROVIDER: S-EPMC10635511 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature