Functionally similar genes exhibit comparable/similar time-course expression kinetics in the UV-induced photoaged mouse model.

ABSTRACT: Skin photoaging induced by ultraviolet (UV) irradiation contributes to the formation of thick and coarse wrinkles. Humans are exposed to UV light throughout their lives. Therefore, it is crucial to determine the time-sequential effects of UV on the skin. In this study, we irradiated the mouse back skin with UV light for eight weeks and observed the changes in gene expressions via microarray analysis every week. There were more downregulated genes (514) than upregulated genes (123). The downregulated genes had more functional diversity than the upregulated genes. Additionally, the number of downregulated genes did not increase in a time-dependent manner. Instead, time-dependent kinetic patterns were observed. Interestingly, each kinetic cluster harbored functionally enriched gene sets. Sinc

SUBMITTER: Jin SP 

PROVIDER: S-EPMC10635544 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature