The microRNA-mediated gene regulatory network in the hippocampus and hypothalamus of the aging mouse.

ABSTRACT: Aging leads to time-dependent functional decline of all major organs. In particular, the aging brain is prone to cognitive decline and several neurodegenerative diseases. Various studies have attempted to understand the aging process and underlying molecular mechanisms by monitoring changes in gene expression in the aging mouse brain using high-throughput sequencing techniques. However, the effect of microRNA (miRNA) on the post-transcriptional regulation of gene expression has not yet been comprehensively investigated. In this study, we performed global analysis of mRNA and miRNA expression simultaneously in the hypothalamus and hippocampus of young and aged mice. We identified aging-dependent differentially expressed genes, most of which were specific either to the hypothalamus or hippoc

SUBMITTER: Munkhzul C 

PROVIDER: S-EPMC10635555 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature