Differential adhesion during development establishes individual neural stem cell niches and shapes adult behaviour in Drosophila.

ABSTRACT: Neural stem cells (NSCs) reside in a defined cellular microenvironment, the niche, which supports the generation and integration of newborn neurons. The mechanisms building a sophisticated niche structure around NSCs and their functional relevance for neurogenesis are yet to be understood. In the Drosophila larval brain, the cortex glia (CG) encase individual NSC lineages in membranous chambers, organising the stem cell population and newborn neurons into a stereotypic structure. We first found that CG wrap around lineage-related cells regardless of their identity, showing that lineage information builds CG architecture. We then discovered that a mechanism of temporally controlled differential adhesion using conserved complexes supports the individual encasing of NSC lineages. An intraline

SUBMITTER: Banach-Latapy A 

PROVIDER: S-EPMC10635556 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature