The seroincidence of childhood Shigella sonnei infection in Ho Chi Minh City, Vietnam.

ABSTRACT:

Background

Shigella sonnei is a pathogen of growing global importance as a cause of diarrhoeal illness in childhood, particularly in transitional low-middle income countries (LMICs). Here, we sought to determine the incidence of childhood exposure to S. sonnei infection in a contemporary transitional LMIC population, where it represents the dominant Shigella species.

Methods

Participants were enrolled between the age of 12-36 months between June and December 2014. Baseline characteristics were obtained through standardized electronic questionnaires, and serum samples were collected at 6-month intervals over two years of follow-up. IgG antibody against S. sonnei O-antigen (anti-O) was measured using an enzyme-linked immunosorbent assay (ELISA). A four-fold increase in ELISA u

SUBMITTER: Jones NK 

PROVIDER: S-EPMC10635567 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature