Sodium-based paracetamol: impact on blood pressure, cardiovascular events, and all-cause mortality.

ABSTRACT:

Background and aims

Effervescent formulations of paracetamol containing sodium bicarbonate have been reported to associate with increased blood pressure and a higher risk of cardiovascular diseases and all-cause mortality. Given the major implications of these findings, the reported associations were re-examined.

Methods

Using linked electronic health records data, a cohort of 475 442 UK individuals with at least one prescription of paracetamol, aged between 60 and 90 years, was identified. Outcomes in patients taking sodium-based paracetamol were compared with those taking non-sodium-based formulations of the same. Using a deep learning approach, associations with systolic blood pressure (SBP), major cardiovascular events (myocardial infarction, heart failure, and stroke),

SUBMITTER: Rao S 

PROVIDER: S-EPMC10635668 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature