Signatures of Neuropsychological Test Results in the Long Life Family Study: A Cluster Analysis.

ABSTRACT:

Background

Discovering patterns of cognitive domains and characterizing how these patterns associate with other risk factors and biomarkers can improve our understanding of the determinants of cognitive aging.

Objective

To discover patterns of cognitive domains using neuropsychological test results in Long Life Family Study (LLFS) and characterize how these patterns associate with aging markers.

Methods

5,086 LLFS participants were administered neuropsychological tests at enrollment. We performed a cluster analysis of six baseline neuropsychological test scores and tested the association between the identified clusters and various clinical variables, biomarkers, and polygenic risk scores using generalized estimating equations and the Chi-square test. We used Cox regre

SUBMITTER: Xiang Q 

PROVIDER: S-EPMC10635779 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature