Total adrenalectomy versus subtotal adrenalectomy for bilateral pheochromocytoma: meta-analysis.

ABSTRACT:

Background

Bilateral pheochromocytomas are rare and often heritable. Total adrenalectomy leads to a definitive oncological cure, with subsequent definitive hypocortisolism. Subtotal adrenalectomy is a possible alternative. The aim of this study was to assess the effects of total adrenalectomy and subtotal adrenalectomy on bilateral pheochromocytoma in terms of post-surgical rate of recurrence, metastatic disease, and steroid dependence.

Methods

Systematic searches in the bibliographic databases PubMed, Embase, and Europe PMC were performed for 1945 to 1 June 2023. PRISMA guidelines were followed and the PICO strategy was applied to English-language studies comparing subtotal adrenalectomy with total adrenalectomy. A random-effects model was used to assess the different outco

SUBMITTER: Schiavone D 

PROVIDER: S-EPMC10635800 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature