Endothelin Receptor Blocker Reverses Breast Cancer-Induced Cardiac Remodeling.

ABSTRACT:

Background

Although some cancer therapies have overt and/or subclinical cardiotoxic effects that increase subsequent cardiovascular risk in breast cancer patients, we have recently shown that the breast tumor itself can also induce cardiac hypertrophy through the activation of the endothelin system to contribute to cardiovascular risk. However, the extent to which the suppression of the activation of the endothelin system could improve cardiac remodeling in breast cancer patients has yet to be investigated.

Objectives

We aimed to retrospectively assess the cardiac morphology/function in patients with breast cancer before receiving cancer chemotherapy and to investigate if the suppression of the activation of the endothelin system improves cardiac remodeling in a mouse model

SUBMITTER: Maayah ZH 

PROVIDER: S-EPMC10635889 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature