Antifibrogenic and apoptotic effects of Ocoxin in cultured rat hepatic stellate cells.

ABSTRACT: Ocoxin is a nutritional supplement that has been shown to exert antioxidant and immunomodulatory responses in patients with chronic hepatitis C. The present work aimed to determine the effects of Ocoxin on activated hepatic stellate cells (HSC), the cell type mainly responsible for collagen deposition in the fibrotic liver. Ocoxin was found to reduce the survival of a cell line of immortalized non-tumoral rat HSC in a dose-response fashion and to diminish collagen type I levels. This latter effect was observed even at doses not affecting cell survival, pointing to an antifibrogenic action for the supplement. The decrease in viability exerted by Ocoxin on HSC correlated with an increase in histone-associated fragments in the cytoplasm and with increased activity of caspase-3, indicating the

SUBMITTER: Ruiz de Galarreta M 

PROVIDER: S-EPMC10635942 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature