Endothelial NOX5 overexpression induces changes in the cardiac gene profile: potential impact in myocardial infarction?

ABSTRACT: Cardiovascular diseases and the ischemic heart disease specifically constitute the main cause of death worldwide. The ischemic heart disease may lead to myocardial infarction, which in turn triggers numerous mechanisms and pathways involved in cardiac repair and remodeling. Our goal in the present study was to characterize the effect of the NADPH oxidase 5 (NOX5) endothelial expression in healthy and infarcted knock-in mice on diverse signaling pathways. The mechanisms studied in the heart of mice were the redox pathway, metalloproteinases and collagen pathway, signaling factors such as NFκB, AKT or Bcl-2, and adhesion molecules among others. Recent studies support that NOX5 expression in animal models can modify the environment and predisposes organ response to harmful stimuli prior to pa

SUBMITTER: Cortes A 

PROVIDER: S-EPMC10635946 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature