Understanding intracranial aneurysm sounds via high-fidelity fluid-structure-interaction modelling.

ABSTRACT:

Background

Since the 1960s, the origins of intracranial aneurysm bruits and musical murmurs have been debated, with proposed mechanisms ranging from self-excitation (i.e., resonance) by stable pulsatile flow, to vibration caused by unstable (laminar vortex shedding or turbulent) flow. This knowledge gap has impeded the use of intracranial sounds a marker of aneurysm remodelling or rupture risk. New computational techniques now allow us to model these phenomena.

Methods

We performed high-fidelity fluid-structure interaction simulations capable of understanding the magnitude and mechanisms of such flow-induced vibrations, under pulsatile flow conditions. Six cases from a previous cohort were used.

Results

In five cases, underlying flow instabilities present as broad-ban

SUBMITTER: Bruneau DA 

PROVIDER: S-EPMC10636010 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature