Neurodegeneration-associated protein VAPB regulates proliferation in medulloblastoma.

ABSTRACT: VAMP (Vesicle-associated membrane protein)-associated protein B and C (VAPB) has been widely studied in neurodegenerative diseases such as ALS, but little is known about its role in cancer. Medulloblastoma is a common brain malignancy in children and arises from undifferentiated cells during neuronal development. Therefore, medulloblastoma is an interesting model to investigate the possible relationship between VAPB and tumorigenesis. Here we demonstrate that high VAPB expression in medulloblastoma correlates with decreased overall patient survival. Consistent with this clinical correlation, we find that VAPB is required for normal proliferation rates of medulloblastoma cells in vitro and in vivo. Knockout of VAPB (VAPB^KO) delayed cell cycle progression. Furthermore, transcript

SUBMITTER: Faria Assoni A 

PROVIDER: S-EPMC10636017 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature