Hippocampal interneuronal dysfunction and hyperexcitability in a porcine model of concussion.

ABSTRACT: Cognitive impairment is a common symptom following mild traumatic brain injury (mTBI or concussion) and can persist for years in some individuals. Hippocampal slice preparations following closed-head, rotational acceleration injury in swine have previously demonstrated reduced axonal function and hippocampal circuitry disruption. However, electrophysiological changes in hippocampal neurons and their subtypes in a large animal mTBI model have not been examined. Using in vivo electrophysiology techniques, we examined laminar oscillatory field potentials and single unit activity in the hippocampal network 7 days post-injury in anesthetized minipigs. Concussion altered the electrophysiological properties of pyramidal cells and interneurons differently in area CA1. While the firing rate, spike

SUBMITTER: Ulyanova AV 

PROVIDER: S-EPMC10636018 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature