Comprehensive analysis of epigenetic and epitranscriptomic genes' expression in human NAFLD.

ABSTRACT: Non-alcoholic fatty liver disease (NAFLD) is a multifactorial condition with a complex etiology. Its incidence is increasing globally in parallel with the obesity epidemic, and it is now considered the most common liver disease in Western countries. The precise mechanisms underlying the development and progression of NAFLD are complex and still poorly understood. The dysregulation of epigenetic and epitranscriptomic mechanisms is increasingly recognized to play pathogenic roles in multiple conditions, including chronic liver diseases. Here, we have performed a comprehensive analysis of the expression of epigenetic and epitranscriptomic genes in a total of 903 liver tissue samples corresponding to patients with normal liver, obese patients, and patients with non-alcoholic fatty liver (NAFL)

SUBMITTER: Herranz JM 

PROVIDER: S-EPMC10636027 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature