Molecular and virulence characteristics of carbapenem-resistant Acinetobacter baumannii isolates: a prospective cohort study.

ABSTRACT: This study aimed to characterize the molecular features and virulence profiles of carbapenem-resistant Acinetobacter baumannii (CRAB) isolates. Clinical CRAB isolates were obtained from blood cultures of adult patients with CRAB bacteremia, collected between July 2015 and July 2021 at a Korean hospital. Real-time polymerase chain reaction was used to detect 13 virulence genes, genotyping was conducted via multilocus sequence typing (MLST), and a Tenebrio molitor infection model was selected for survival analysis. Herein, 170 patients, from whom CRAB isolates were collected, showed the in-hospital mortality rate of 57.6%. All 170 clinical CRAB isolates harbored bla_OXA-23 and bla_OXA-51. MLST genotyping identified 11 CRAB sequence types (STs), of which ST191 was predomin

SUBMITTER: Park SM 

PROVIDER: S-EPMC10636183 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature