Wide-field endoscope accessory for multiplexed fluorescence imaging.

ABSTRACT: A wide-field endoscope that is sensitive to fluorescence can be used as an adjunct to conventional white light endoscopy by detecting multiple molecular targets concurrently. We aim to demonstrate a flexible fiber-coupled accessory that can pass forward through the instrument channel of standard medical endoscopes for clinical use to collect fluorescence images. A miniature scan mirror with reflector dimensions of 1.30 × 0.45  mm² was designed, fabricated, and placed distal to collimated excitation beams at λ_ex = 488, 660, and 785 nm. The mirror was driven at resonance for wide angular deflections in the X and Y-axes. A large image field-of-view (FOV) was generated in real time. The optomechanical components were packaged in a rigid distal tip with dimensions of 2.6 m

SUBMITTER: Li G 

PROVIDER: S-EPMC10636199 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature