Dataset Information

Factors influencing cognitive function in patients with Huntington's disease from China: A cross-sectional clinical study.

ABSTRACT:

Background and aim

Huntington's disease (HD) is an autosomal dominant inherited neurodegenerative disorder caused by CAG repeats expansion. Cognitive decline contributes to the loss of daily activity in manifest HD. We aimed to examine the cognition status in a Chinese HD cohort and explore factors influencing the diverse cognitive domains.

Methods

A total of 205 participants were recruited in the study with the assessment by neuropsychological batteries, including the mini-mental state examination (MMSE), Stroop test, symbol digit modalities test (SDMT), trail making test (TMT), verbal fluency test (VFT), and Hopkins verbal learning test-revised, as well as motor and psychiatric assessment. Pearson correlation and multiple linear regression models were applied to investigate the correlation.

Results

Only 41.46% of patients had normal global function first come to our center. There was a significantly difference in MMSE, Stroop test, SDMT, TMT, and VFT across each stage of HD patients (p < .05). Apathy of PBA-s was correlated to MMSE, animal VFT and Stroop-interference tests performance. Severity of motor symptoms, functional capacity, age, and age of motor symptom onset were correlated to all neuropsychological scores, whereas education attainment and diagnostic delay were correlated to most neuropsychological scores except TMT. Severity of motor symptoms, functional capacity, and education attainment showed independent predicting effect (p < .05) in diverse cognitive domains.

Conclusion

Cognitive impairment was very common in Chinese HD patients at the first visit and worse in the patients in advanced phase. The severity of motor symptoms and functional capacity were correlated to the diverse cognitive domains.

SUBMITTER: Cheng YF

PROVIDER: S-EPMC10636378 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature

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Publications

Factors influencing cognitive function in patients with Huntington's disease from China: A cross-sectional clinical study.

Cheng Yang-Fan YF Liu Kun-Cheng KC Yang Tian-Mi TM Xiao Yi Y Jiang Qi-Rui QR Huang Jing-Xuan JX Zhang Sirui S Wei Qian-Qian QQ Ou Ru-Wei RW Li Chun-Yu CY Gu Xiao-Jing XJ Burgunder Jean-Marc JM Shang Hui-Fang HF

Brain and behavior 20231017 11

<h4>Background and aim</h4>Huntington's disease (HD) is an autosomal dominant inherited neurodegenerative disorder caused by CAG repeats expansion. Cognitive decline contributes to the loss of daily activity in manifest HD. We aimed to examine the cognition status in a Chinese HD cohort and explore factors influencing the diverse cognitive domains.<h4>Methods</h4>A total of 205 participants were recruited in the study with the assessment by neuropsychological batteries, including the mini-mental ...[more]

PMID: 37849450

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Dataset Information

Factors influencing cognitive function in patients with Huntington's disease from China: A cross-sectional clinical study.

Background and aim

Methods

Results

Conclusion

Publications

Factors influencing cognitive function in patients with Huntington's disease from China: A cross-sectional clinical study.

Similar Datasets

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