Association between COVID-19 and myasthenia gravis (MG): A genetic correlation and Mendelian randomization study.

ABSTRACT:

Background

Observational studies have suggested an association between coronavirus disease 2019 (COVID-19) and myasthenia gravis (MG). Here, we aimed to estimate the genetic correlation and causal relationship between COVID-19 susceptibility, hospitalization, severity, and MG phenotypes using linkage disequilibrium score regression (LDSC) and Mendelian randomization (MR) approach.

Methods

Summary statistics of COVID-19 susceptibility, hospitalization, and severity were used as instrumental variables for exposure traits. Large-scale genome-wide association study (GWAS) data for MG were used as outcome traits. The inverse variance weighted approach was used for the main MR analysis, complemented by MR-Egger, weighted median, simple mode, and weighted mode methods. Sensitivity

SUBMITTER: Sun D 

PROVIDER: S-EPMC10636397 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature