Blood biomarker changes following therapeutic hypothermia in ischemic stroke.

ABSTRACT:

Introduction

Therapeutic hypothermia is a promising candidate for stroke treatment although its efficacy has not yet been demonstrated in patients. Changes in blood molecules could act as surrogate markers to evaluate the efficacy and safety of therapeutic cooling.

Methods

Blood samples from 54 patients included in the EuroHYP-1 study (27 treated with hypothermia, and 27 controls) were obtained at baseline, 24 ± 2 h, and 72 ± 4 h. The levels of a panel of 27 biomarkers, including matrix metalloproteinases and cardiac and inflammatory markers, were measured.

Results

Metalloproteinase-3 (MMP-3), fatty-acid-binding protein (FABP), and interleukin-8 (IL-8) increased over time in relation to the hypothermia treatment. Statistically significant correlations between the mini

SUBMITTER: Pala E 

PROVIDER: S-EPMC10636403 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature