Disturbance of skin sensation and autism spectrum disorder: A bidirectional Mendelian randomization study.

ABSTRACT:

Background and aim

Patients with autism spectrum disorder (ASD) commonly experience aberrant skin sensation sensitivity; however, the causal relationship is not yet clear. This study uses a bidirectional Mendelian randomization (MR) method to explore the relationship between disturbance of skin sensation (DSS) and ASD.

Methods

Single-nucleotide polymorphisms (SNPs) extracted from the summary data of genome-wide association studies were used as genetic instruments. MR was performed using the inverse-variance-weighted method, with alternate methods (e.g., weighted median, MR-Egger, simple mode, weighted mode, and MR-pleiotropy residual sum and outlier) and multiple sensitivity analyses to assess horizontal pleiotropy and remove outliers.

Results

The results of the analy

SUBMITTER: Zhong X 

PROVIDER: S-EPMC10636404 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature