Circulomic variables predict pathologic staging preoperatively in treatment-naive non-small cell lung cancer.

ABSTRACT: Therapeutic decisions in non-small cell lung cancer (NSCLC) are stage-dependent, and, consequently, changes in an individual's stage carry potential for substantial alterations in management. Malignancy-related disturbances of the circulomic inflammatory environment may affect platelets quantitatively, ultimately leading to changes in tumor characteristics. Our objective was to identify circulomic characteristics associated with upstaging among chemotherapy-naïve patients with resected NSCLC and to assess the consequent impact on overall survival (OS). A retrospective review of a prospectively maintained thoracic surgery database was performed, identifying chemotherapy-naïve patients who underwent resection of clinical stage I-III NSCLC between 1998 and 2021. Clinicopathologic characterist

SUBMITTER: Deboever N 

PROVIDER: S-EPMC10636430 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature