Neutrophil bactericidal activity and host defenses in cystic fibrosis: a narrative review.

ABSTRACT:

Background and objective

Cystic fibrosis (CF) is a disorder that affects the cystic fibrosis transmembrane conductance regulator (CFTR). Without properly functioning CFTR channels, chloride does not exit respiratory epithelial cells, and consequently the mucus lining the surface of the cells becomes thick. This viscous mucus accumulates and causes abnormal function of the mucociliary apparatus, which can lead to bacterial colonization, infections with Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa (P. aeruginosa), and eventually lung damage. Recent studies have shown that the increased susceptibility to respiratory infections in CF patients may also be due to defects in neutrophil function, but the exact mechanism is uncertain.

Methods</

SUBMITTER: Patel S 

PROVIDER: S-EPMC10636459 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature