Identification of potential biomarkers associated with CD4⁺ T cell infiltration in myocardial ischemia-reperfusion injury using bioinformation analysis.

ABSTRACT:

Background

Myocardial ischemia-reperfusion injury (MIRI) is often part of clinical events such as cardiac arrest, resuscitation, and reperfusion after coronary artery occlusion. Recently, more and more studies have shown that the immune microenvironment is an integral part of ischemia-reperfusion injury (IRI), and CD4⁺ T-cell infiltration plays an important role, but there are no relevant molecular targets for clinical diagnosis and treatment.

Methods

The transcriptome data and matched group information were retrieved from the Gene Expression Omnibus (GEO) database. The ImmuCellAI-mouse (Immune Cell Abundance Identifier for mouse) algorithm was used to calculate each symbol's CD4⁺ T cell infiltration score. The time period with the greatest change in th

SUBMITTER: Wang W 

PROVIDER: S-EPMC10636474 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature