Understanding the relationship between loneliness, substance use traits and psychiatric disorders: A genetically informed approach.

ABSTRACT: Loneliness is a common, yet distressing experience associated with adverse outcomes including substance use problems and psychiatric disorders. To what extent these associations reflect genetic correlations and causal relationships is currently unclear. We applied Genomic Structural Equation Modelling (GSEM) to dissect the genetic architecture between loneliness and psychiatric-behavioural traits. Included were summary statistics from 12 genome-wide association analyses, including loneliness and 11 psychiatric phenotypes (range N: 9,537 - 807,553). We first modelled latent genetic factors amongst the psychiatric traits to then investigate potential causal effects between loneliness and the identified latent factors, using multivariate genome-wide association analyses and bidirectional Mend

SUBMITTER: Martin E 

PROVIDER: S-EPMC10636586 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature