Accurate Bayesian segmentation of thalamic nuclei using diffusion MRI and an improved histological atlas.

ABSTRACT: The human thalamus is a highly connected brain structure, which is key for the control of numerous functions and is involved in several neurological disorders. Recently, neuroimaging studies have increasingly focused on the volume and connectivity of the specific nuclei comprising this structure, rather than looking at the thalamus as a whole. However, accurate identification of cytoarchitectonically designed histological nuclei on standard in vivo structural MRI is hampered by the lack of image contrast that can be used to distinguish nuclei from each other and from surrounding white matter tracts. While diffusion MRI may offer such contrast, it has lower resolution and lacks some boundaries visible in structural imaging. In this work, we present a Bayesian segmentation algorithm for the

SUBMITTER: Tregidgo HFJ 

PROVIDER: S-EPMC10636587 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature