Botulinum neurotoxin A modulates the axonal release of pathological tau in hippocampal neurons.

ABSTRACT: Pathological tau aggregates propagate across functionally connected neuronal networks in human neurodegenerative pathologies, such as Alzheimer's disease. However, the mechanism underlying this process is poorly understood. Several studies have showed that tau release is dependent on neuronal activity and that pathological tau is found in the extracellular space in free form, as well as in the lumen of extracellular vesicles. We recently showed that metabotropic glutamate receptor activity and SNAP25 integrity modulate the release of pathological tau from human and mouse synaptosomes. Here, we have leveraged botulinum neurotoxins (BoNTs), which impair neurotransmitter release by cleaving specific synaptic SNARE proteins, to dissect molecular mechanisms related to tau release at synapses. I

SUBMITTER: Panzi C 

PROVIDER: S-EPMC10636589 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature