The value of blood-based measures of liver function and urate in lung cancer risk prediction: A cohort study and health economic analysis.

ABSTRACT:

Background

Several studies have reported associations between low-cost blood-based measurements and lung cancer but their role in risk prediction is unclear. We examined the value of expanding lung cancer risk models for targeting low-dose computed tomography (LDCT), including blood measurements of liver function and urate.

Methods

We analysed a cohort of 388,199 UK Biobank participants with 1873 events and calculated the c-index and fraction of new information (FNI) for models expanded to include combinations of blood measurements, lung function (forced expiratory volume in 1 s - FEV₁), alcohol status and waist circumference. We calculated the hypothetical cost per lung cancer case detected by LDCT for different scenarios using a threshold of ≥ 1.51 % risk at 6 y

SUBMITTER: Horsfall LJ 

PROVIDER: S-EPMC10636591 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature