SLeX Expression Delineates Distinct Functional Subsets of Human Blood Central and Effector Memory T Cells.

ABSTRACT: Sialyl Lewis X (sLeX) regulates T cell trafficking from the vasculature into skin and sites of inflammation, thereby playing a critical role in immunity. In healthy persons, only a small proportion of human blood T cells express sLeX, and their function is not fully defined. Using a combination of biochemical and functional studies, we find that human blood sLeX⁺CD4⁺T cells comprise a subpopulation expressing high levels of Th2 and Th17 cytokines, chemokine receptors CCR4 and CCR6, and the transcription factors GATA-3 and RORγT. Additionally, sLeX⁺CD4⁺T cells exclusively contain the regulatory T cell population (CD127^lowCD25^high and FOXP3⁺) and characteristically display immune-suppressive molecules, including the

SUBMITTER: Silva M 

PROVIDER: S-EPMC10636707 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature