High-Throughput Screening of Thiol-ene Click Chemistries for Bone Adhesive Polymers.

ABSTRACT: Metal surgical pins and screws are employed in millions of orthopedic surgical procedures every year worldwide, but their usability is limited in the case of complex, comminuted fractures or in surgeries on smaller bones. Therefore, replacing such implants with a bone adhesive material has long been considered an attractive option. However, synthesizing a biocompatible bone adhesive with a high bond strength that is simple to apply presents many challenges. To rapidly identify candidate polymers for a biocompatible bone adhesive, we employed a high-throughput screening strategy to assess human mesenchymal stromal cell (hMSC) adhesion toward a library of polymers synthesized via thiol-ene click chemistry. We chose thiol-ene click chemistry because multifunctional monomers can be rapidly cur

SUBMITTER: Ganabady K 

PROVIDER: S-EPMC10636719 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature