Aggregated Hendra virus C-protein activates the NLRP3 inflammasome to induce inflammation.

ABSTRACT:

Background

Hendra virus is an emerging virus with a geographically broad host reservoir. In humans, Hendra virus causes excessive inflammatory disease of the lung and nervous system. Our current understanding as to how Hendra virus or what factors induce inflammation is limited and as such, there are currently no therapeutic options available for patients who contract Hendra virus. Recent studies have identified viral aggregating proteins as drivers of inflammation in influenza A virus and SARS-CoV-2 virus. In this study, we sought to identify potential aggregating Hendra virus proteins as proof-of-concept that inflammasome activation may induce inflammation and contribute to disease pathology.

Results

Here, we have identified that a peptide analogue of Hendra virus C protei

SUBMITTER: Barry K 

PROVIDER: S-EPMC10636811 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature