Regulation of the Hippo/YAP axis by CXCR7 in the tumorigenesis of gastric cancer.

ABSTRACT:

Background

The Hippo pathway is crucial in organ size control and tumorigenesis. Dysregulation of the Hippo/YAP axis is commonly observed in gastric cancer, while effective therapeutic targets for the Hippo/YAP axis are lacking. Identification of reliable drug targets and the underlying mechanisms that could inhibit the activity of the Hippo/YAP axis and gastric cancer progression is urgently needed.

Methods

We used several gastric cancer cell lines and xenograft models and performed immunoblotting, qPCR, and in vivo studies to investigate the function of CXCR7 in gastric cancer progression.

Results

In our current study, we demonstrate that the membrane receptor CXCR7 (C-X-C chemokine receptor 7) is an important modulator of the Hippo/YAP axis. The activation of CXCR7

SUBMITTER: Wang T 

PROVIDER: S-EPMC10636825 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature