P63 orchestrates serine and one carbon metabolism enzymes expression in head and neck cancer.

ABSTRACT:

Background

Head and neck squamous cell carcinoma (HNSCC) is characterized by high proliferation and limited differentiation. The altered expression of the p53 family members, and specifically of p63, represents a pivotal event in the pathogenesis of HNSCC. Physiologically, p63 affects metabolism through the direct transactivation of the enzyme hexokinase 2, and subsequently controls the proliferation of epithelial cells; nonetheless, its role in cancer metabolism is still largely unclear. The high energetic demand of cancer and the consequent needs of a metabolic reshape, also involve the serine and glycine catabolic and anabolic pathways, including the one carbon metabolism (OCM), to produce energetic compounds (purines) and to maintain cellular homeostasis (glutathione and S-aden

SUBMITTER: Cappello A 

PROVIDER: S-EPMC10636826 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature