Genetic risk scores: are they important for diabetes management? results from multiple cross-sectional studies.

ABSTRACT:

Background

Several genetic risk scores (GRS) for type 2 diabetes (T2DM) have been published, but not replicated. We aimed to 1) replicate previous findings on the association between GRS on prevalence of T2DM and 2) assess the association between GRS and T2DM management in a sample of community-dwelling people from Switzerland.

Methods

Four waves from a prospective study conducted in Lausanne. Seven GRS related to T2DM were selected, and compared between participants with and without T2DM, and between controlled and uncontrolled participants treated for T2DM.

Results

Data from 5426, 4017, 2873 and 2170 participants from the baseline, first, second and third follow-ups, respectively, was used. In all study periods, participants with T2DM scored higher than participants

SUBMITTER: Nagarajah S 

PROVIDER: S-EPMC10636836 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature