M2 macrophage-derived cathepsin S promotes peripheral nerve regeneration via fibroblast-Schwann cell-signaling relay.

ABSTRACT:

Background

Although peripheral nerves have an intrinsic self-repair capacity following damage, functional recovery is limited in patients. It is a well-established fact that macrophages accumulate at the site of injury. Numerous studies indicate that the phenotypic shift from M1 macrophage to M2 macrophage plays a crucial role in the process of axon regeneration. This polarity change is observed exclusively in peripheral macrophages but not in microglia and CNS macrophages. However, the molecular basis of axonal regeneration by M2 macrophage is not yet fully understood. Herein, we aimed to identify the M2 macrophage-derived axon regeneration factor.

Methods

We established a peripheral nerve injury model by transection of the inferior alveolar nerve (IANX) in Sprague-Dawley r

SUBMITTER: Oshima E 

PROVIDER: S-EPMC10636844 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature