Lysine lactylation (Kla) might be a novel therapeutic target for breast cancer.

ABSTRACT:

Background

Histone lysine lactylation (Kla) is a newly identified histone modification, which plays a crucial role in cancer progression. Hence, we determined the prognostic value of Kla in breast cancer (BC).

Methods

We obtained RNA expression profiles of BC from The Cancer Genome Atlas (TCGA), following screening out Kla-specific genes. Furthermore, we determined the prognostic value of Kla by constructing a cox model based on Kla-specific genes. Subsequently, we identified expression of lactate accumulation-related genes and prognostic Kla-specific genes through Human Protein Atlas (HPA), and further performed a correlation analysis based on their expression. Meanwhile, we explored the effects of Kla on BC tumor microenvironment (TME), drug therapy and immunotherapy. More

SUBMITTER: Deng J 

PROVIDER: S-EPMC10636881 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature