Identification of ferroptosis-related genes in acute phase of temporal lobe epilepsy based on bioinformatic analysis.

ABSTRACT:

Background

Epilepsy is a prevalent neurological disorder, and while its precise mechanism remains elusive, a connection to ferroptosis has been established. This study investigates the potential clinical diagnostic significance of ferroptosis-related genes (FRGs) during the acute phase of temporal lobe epilepsy.

Methods

To identify differentially expressed genes (DEGs), we accessed data from the GEO database and performed an intersection analysis with the FerrDB database to pinpoint FRGs. A protein-protein interaction (PPI) network was constructed. To assess the diagnostic utility of the discovered feature genes for the disease, ROC curve analysis was conducted. Subsequently, qRT-PCR was employed to validate the expression levels of these feature genes.

Results

This s

SUBMITTER: Chen S 

PROVIDER: S-EPMC10636915 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature