ITRAQ-based proteomics reveals potential markers and treatment pathways for acute Achilles tendon rupture.

ABSTRACT:

Background

Due to its limited blood supply and irregular mechanical loading, the Achilles tendon is the most frequently ruptured tendon. Despite the rising incidence of acute Achilles tendon rupture (AATR), the optimal treatment remains controversial. Missed diagnoses and delayed treatments lead to poor outcomes and limited treatment options. This study aimed to identify potential biomarkers for diagnosing and developing therapies for AATR.

Methods

We employed the coupled isobaric tag for relative and absolute quantitation-liquid chromatography-electrospray ionization-tandem mass spectrometry approach to investigate protein expression in tissues from AATR patients. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were conducted to ide

SUBMITTER: Qianman B 

PROVIDER: S-EPMC10636927 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature