Rapid profiling of Plasmodium parasites from genome sequences to assist malaria control.

ABSTRACT:

Background

Malaria continues to be a major threat to global public health. Whole genome sequencing (WGS) of the underlying Plasmodium parasites has provided insights into the genomic epidemiology of malaria. Genome sequencing is rapidly gaining traction as a diagnostic and surveillance tool for clinical settings, where the profiling of co-infections, identification of imported malaria parasites, and detection of drug resistance are crucial for infection control and disease elimination. To support this informatically, we have developed the Malaria-Profiler tool, which rapidly (within minutes) predicts Plasmodium species, geographical source, and resistance to antimalarial drugs directly from WGS data.

Results

The online and command line versions of Malaria-Profiler detect ~ 2

SUBMITTER: Phelan JE 

PROVIDER: S-EPMC10636944 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature