Causal effect between gut microbiota and pancreatic cancer: a two-sample Mendelian randomization study.

ABSTRACT:

Background

Gut microbiota (GM) comprises a vast and diverse community of microorganisms, and recent studies have highlighted the crucial regulatory roles of various GM and their secreted metabolites in pancreatic cancer (PC). However, the causal relationship between GM and PC has yet to be confirmed.

Methods

In the present study, we used two-sample Mendelian randomization (MR) analysis to investigate the causal effect between GM and PC, with genome-wide association study (GWAS) from MiBioGen consortium as an exposure factor and PC GWAS data from FinnGen as an outcome factor. Inverse variance weighted (IVW) was used as the primary method for this study.

Results

At the genus level, we observed that Senegalimassilia (OR: 0.635, 95% CI: 0.403-0.998, P = 0.049) exhibited a

SUBMITTER: Jiang Z 

PROVIDER: S-EPMC10636952 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature