RC48-ADC treatment for patients with HER2-expressing locally advanced or metastatic solid tumors: a real-world study.

ABSTRACT:

Background

RC48-antibody-drug conjugates (ADC) link humanized anti-HER2 immunoglobulin with monomethyl auristatin E (MMAE). Clinical trials suggest promising antitumor activity in HER2-expressing solid tumors. This study probes RC48-ADC's efficacy and safety in patients with HER2-expressing advanced or metastatic solid tumors.

Method

Data was collected from 23 advanced cancer patients treated with RC48-ADC at our oncology center between July 2021 and December 2022. These patients exhibited at least 1 + expression of HER2 immunohistochemistry, had previously experienced at least one failed systemic chemotherapy, and were treated with RC48-ADC until the occurrence of intolerable adverse reactions or disease progression. The primary endpoint was the disease control rate (DCR),

SUBMITTER: Wang P 

PROVIDER: S-EPMC10636982 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature